ACALEPH(E)
\ɐkˈalɛf ˈiː], \ɐkˈalɛf ˈiː], \ɐ_k_ˈa_l_ɛ_f__ ˈiː]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.