ACIDIC FIBROBLAST GROWTH FACTOR
\ɐsˈɪdɪk fˈɪbɹəblˌast ɡɹˈə͡ʊθ fˈaktə], \ɐsˈɪdɪk fˈɪbɹəblˌast ɡɹˈəʊθ fˈaktə], \ɐ_s_ˈɪ_d_ɪ_k f_ˈɪ_b_ɹ_ə_b_l_ˌa_s_t ɡ_ɹ_ˈəʊ_θ f_ˈa_k_t_ə]\
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A 17 kD single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.