BORTHEN'S OPERATION
\bˈɔːðənz ˌɒpəɹˈe͡ɪʃən], \bˈɔːðənz ˌɒpəɹˈeɪʃən], \b_ˈɔː_ð_ə_n_z ˌɒ_p_ə_ɹ_ˈeɪ_ʃ_ə_n]\
Definitions of BORTHEN'S OPERATION
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.