BUTTONHOLE OPERATION
\bˈʌtənhˌə͡ʊl ˌɒpəɹˈe͡ɪʃən], \bˈʌtənhˌəʊl ˌɒpəɹˈeɪʃən], \b_ˈʌ_t_ə_n_h_ˌəʊ_l ˌɒ_p_ə_ɹ_ˈeɪ_ʃ_ə_n]\
Definitions of BUTTONHOLE OPERATION
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By Willam Alexander Newman Dorland
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.