CARL CHRISTIAN RAFN

\kˈɑːl kɹˈɪst͡ʃən ɹˈafən], \kˈɑːl kɹˈɪst‍ʃən ɹˈafən], \k_ˈɑː_l k_ɹ_ˈɪ_s_tʃ_ə_n ɹ_ˈa_f_ə_n]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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