CASSETTE MUTAGENESIS
\kɐsˈɛt mjˌuːte͡ɪd͡ʒˈɛnɪsˌɪs], \kɐsˈɛt mjˌuːteɪdʒˈɛnɪsˌɪs], \k_ɐ_s_ˈɛ_t m_j_ˌuː_t_eɪ_dʒ_ˈɛ_n_ɪ_s_ˌɪ_s]\
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Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA can be inserted into or adjacent to a cellular proto-oncogene. Insertion of the provirus can cause mutations by interrupting coding sequences or regulatory elements, or cause unregulated expression of the proto-oncogene resulting in tumor formation.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.