DEBRISOQUINE
\dˈɛbɹɪsˌɒkwa͡ɪn], \dˈɛbɹɪsˌɒkwaɪn], \d_ˈɛ_b_ɹ_ɪ_s_ˌɒ_k_w_aɪ_n]\
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An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
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