DEJERINE ROUSSY SYNDROME
\dɪd͡ʒˈɛɹiːn ɹˈa͡ʊsi sˈɪndɹə͡ʊm], \dɪdʒˈɛɹiːn ɹˈaʊsi sˈɪndɹəʊm], \d_ɪ_dʒ_ˈɛ_ɹ_iː_n ɹ_ˈaʊ_s_i s_ˈɪ_n_d_ɹ_əʊ_m]\
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Disorders of the centrally located thalamus, which integrates a wide range of cortical and subcortical information. Manifestations include sensory loss, MOVEMENT DISORDERS; ATAXIA, pain syndromes, visual disorders, a variety of neuropsychological conditions, and COMA. Relatively common etiologies include CEREBROVASCULAR DISORDERS; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; BRAIN HYPOXIA; INTRACRANIAL HEMORRHAGES; and infectious processes.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.