EAN (EXPERIMENTAL AUTOIMMUNE NEURITIS)
\ˌiːˌe͡ɪˈɛn ɛkspˌɛɹɪmˈɛntə͡l ˌɔːtə͡ʊɪmjˈuːn njuːɹˈa͡ɪtɪs], \ˌiːˌeɪˈɛn ɛkspˌɛɹɪmˈɛntəl ˌɔːtəʊɪmjˈuːn njuːɹˈaɪtɪs], \ˌiː__ˌeɪ_ˈɛ_n__ ɛ_k_s_p_ˌɛ_ɹ_ɪ_m_ˈɛ_n_t_əl ˌɔː_t_əʊ_ɪ_m_j_ˈuː_n n_j_uː_ɹ_ˈaɪ_t_ɪ_s]\
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An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84 (1):40-52)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.
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