ECL CELLS
\ˌiːsˌiːˈɛl sˈɛlz], \ˌiːsˌiːˈɛl sˈɛlz], \ˌiː_s_ˌiː__ˈɛ_l s_ˈɛ_l_z]\
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Irregular-shaped argyrophilic cells which produce histamine, chromogranin A/pancreastatin, and an as yet unidentified peptide hormone. They are the predominant endocrine cell type of the oxyntic (acid-producing) mucosa of the stomach. ECL cells respond to gastrin by releasing their secretory products and this source of histamine acts as the positive paracrine stimulator of the release of hydrochloric acid from the parietal cell.
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.