EXTRAMAMMARY PAGETS DISEASE
\ˈɛkstɹəmˌaməɹi pˈaɡɪts dɪzˈiːz], \ˈɛkstɹəmˌaməɹi pˈaɡɪts dɪzˈiːz], \ˈɛ_k_s_t_ɹ_ə_m_ˌa_m_ə_ɹ_i p_ˈa_ɡ_ɪ_t_s d_ɪ_z_ˈiː_z]\
Sort: Oldest first
-
A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.