FOLIC ACID ANTAGONISTS
\fˈɒlɪk ˈasɪd antˈaɡənˌɪsts], \fˈɒlɪk ˈasɪd antˈaɡənˌɪsts], \f_ˈɒ_l_ɪ_k ˈa_s_ɪ_d a_n_t_ˈa_ɡ_ə_n_ˌɪ_s_t_s]\
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Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
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