GERANYLGERANYLATION
\d͡ʒˌɛɹɐnˌɪld͡ʒəɹˌanɪlˈe͡ɪʃən], \dʒˌɛɹɐnˌɪldʒəɹˌanɪlˈeɪʃən], \dʒ_ˌɛ_ɹ_ɐ_n_ˌɪ_l_dʒ_ə_ɹ_ˌa_n_ɪ_l_ˈeɪ_ʃ_ə_n]\
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A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.