GLIOBLASTOMA MULTIFORME
\ɡlɪˌɒblastˈə͡ʊmə mˌʌltɪfˈɔːm], \ɡlɪˌɒblastˈəʊmə mˌʌltɪfˈɔːm], \ɡ_l_ɪ__ˌɒ_b_l_a_s_t_ˈəʊ_m_ə m_ˌʌ_l_t_ɪ_f_ˈɔː_m]\
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A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
Nearby Words
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