HISTORICAL ARTICLE

\hɪstˈɒɹɪkə͡l ˈɑːtɪkə͡l], \hɪstˈɒɹɪkə‍l ˈɑːtɪkə‍l], \h_ɪ_s_t_ˈɒ_ɹ_ɪ_k_əl ˈɑː_t_ɪ_k_əl]\

Definitions of HISTORICAL ARTICLE

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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