LEO DI CASTELNOVO

\lˈiːə͡ʊ dˌɪ kˌastɪlnˈə͡ʊvə͡ʊ], \lˈiːə‍ʊ dˌɪ kˌastɪlnˈə‍ʊvə‍ʊ], \l_ˈiː__əʊ d_ˌɪ k_ˌa_s_t_ɪ_l_n_ˈəʊ_v_əʊ]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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