LEVOTETRAMISOLE
\lˈɛvə͡ʊttɹˌamɪsˌə͡ʊl], \lˈɛvəʊttɹˌamɪsˌəʊl], \l_ˈɛ_v_əʊ_t_t_ɹ_ˌa_m_ɪ_s_ˌəʊ_l]\
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An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.