LISTERIA MENINGOENCEPHALITIDES
\lɪstˈi͡əɹɪə mˈɛnɪŋɡˌə͡ʊnsɪfˌalɪtˌa͡ɪdz], \lɪstˈiəɹɪə mˈɛnɪŋɡˌəʊnsɪfˌalɪtˌaɪdz], \l_ɪ_s_t_ˈiə_ɹ_ɪ__ə m_ˈɛ_n_ɪ_ŋ_ɡ_ˌəʊ_n_s_ɪ_f_ˌa_l_ɪ_t_ˌaɪ_d_z]\
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Inflammation of the meninges caused by LISTERIA MONOCYTOGENES infection, usually occuring in individuals under the age of 3 years or over the age of 50 years. It may occur at any age in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. Clinical manifestations include FEVER, altered mentation, HEADACHE, meningeal signs, focal neurologic signs, and SEIZURES. (From Medicine 1998 Sep;77 (5):313-36)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.