METALLOPROTEINASES TISSUE INHIBITOR
\mˈɛtə͡lˌɒpɹə͡ʊtˌɪne͡ɪsɪz tˈɪʃuː ɪnhˈɪbɪtə], \mˈɛtəlˌɒpɹəʊtˌɪneɪsɪz tˈɪʃuː ɪnhˈɪbɪtə], \m_ˈɛ_t_əl_ˌɒ_p_ɹ_əʊ_t_ˌɪ_n_eɪ_s_ɪ_z t_ˈɪ_ʃ_uː ɪ_n_h_ˈɪ_b_ɪ_t_ə]\
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A family of secreted proteins (TIMP-1; TIMP-2; and TIMP-3) that play a crucial role in regulating the activity of the secreted METALLOENDOPEPTIDASES (COLLAGENASES; stromelysins, GELATINASES). Of the three characterized, only TIMP-1 and TIMP-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.