NONVOLUNTARY

\nˌɒnvˈɒləntəɹi], \nˌɒnvˈɒləntəɹi], \n_ˌɒ_n_v_ˈɒ_l_ə_n_t_ə_ɹ_i]\
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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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