ORYZACYSTATIN
\ˈɒɹɪzˌasɪstˌatɪn], \ˈɒɹɪzˌasɪstˌatɪn], \ˈɒ_ɹ_ɪ_z_ˌa_s_ɪ_s_t_ˌa_t_ɪ_n]\
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A homologous group of endogenous cysteine proteinase inhibitors. Four distinct families are recognized within the cystatin superfamily: cystatin B or stefins; cystatin C or post-gamma-globulin; egg-white or chicken cystatin; and kininogen cystatin. The cystatins inhibit most Cysteine Endopeptidases of the papain type, and other peptidases which have a sulfhydryl group at the active site.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.