PALATE PLATE
\pˈalət plˈe͡ɪt], \pˈalət plˈeɪt], \p_ˈa_l_ə_t p_l_ˈeɪ_t]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.