PHARMACOEPIDEMIOLOGY
\fˌɑːmɐkˌə͡ʊpa͡ɪdmɪˈɒləd͡ʒi], \fˌɑːmɐkˌəʊpaɪdmɪˈɒlədʒi], \f_ˌɑː_m_ɐ_k_ˌəʊ_p_aɪ_d_m_ɪ__ˈɒ_l_ə_dʒ_i]\
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The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1 (1); J Pharmacoepidemiol 1990;1 (1))
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.