THAPSIGARGIN
\θˈapsɪɡˌɑːd͡ʒɪn], \θˈapsɪɡˌɑːdʒɪn], \θ_ˈa_p_s_ɪ_ɡ_ˌɑː_dʒ_ɪ_n]\
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A potent skin irritating sesquiterpene lactone isolated from the roots of Thapsia garganica L. (Apiaceae). It also acts as a non-phorbol-ester-type tumor promoter which discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca (2+)-ATPase. (Biochem Pharmacol 1987;36 (5):621-6; Proc Natl Acad Sci USA 1991;88 (16):7096-100)
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Snake's-head
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