TOPPLING
\tˈɒplɪŋ], \tˈɒplɪŋ], \t_ˈɒ_p_l_ɪ_ŋ]\
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falling over as if from top-heaviness or lack of support; "a toppling pile of books"; "toppling empires"
By Princeton University
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.