TOTALITARIANISM

\tə͡ʊtˌalɪtˈe͡əɹi͡ənˌɪzəm], \tə‍ʊtˌalɪtˈe‍əɹi‍ənˌɪzəm], \t_əʊ_t_ˌa_l_ɪ_t_ˈeə_ɹ_iə_n_ˌɪ_z_ə_m]\

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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