TRIETHYLENETHIOPHOSPHORAMIDE
\tɹˈa͡ɪθa͡ɪlnˌɛθɪˌɒfəsfˌɔːɹɐmˌa͡ɪd], \tɹˈaɪθaɪlnˌɛθɪˌɒfəsfˌɔːɹɐmˌaɪd], \t_ɹ_ˈaɪ_θ_aɪ_l_n_ˌɛ_θ_ɪ__ˌɒ_f_ə_s_f_ˌɔː_ɹ_ɐ_m_ˌaɪ_d]\
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A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.