UNSTABLE DNA SEQUENCES
\ʌnstˈe͡ɪbə͡l dˌiːˌɛnˈe͡ɪ sˈiːkwənsɪz], \ʌnstˈeɪbəl dˌiːˌɛnˈeɪ sˈiːkwənsɪz], \ʌ_n_s_t_ˈeɪ_b_əl d_ˌiː__ˌɛ_n_ˈeɪ s_ˈiː_k_w_ə_n_s_ɪ_z]\
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DNA region comprised of a variable number of repetitive, contiguous trinucleotide sequences. The presence of these regions is associated with diseases such as Fragile X Syndrome and MYOTONIC DYSTROPHY. Many chromosome fragile sites (CHROMOSOME FRAGILITY) contain expanded trinucleotide repeats.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.