CHRONIC ACTINIC DERMATITIDES
\kɹˈɒnɪk aktˈɪnɪk dˈɜːmɐtˌɪta͡ɪdz], \kɹˈɒnɪk aktˈɪnɪk dˈɜːmɐtˌɪtaɪdz], \k_ɹ_ˈɒ_n_ɪ_k a_k_t_ˈɪ_n_ɪ_k d_ˈɜː_m_ɐ_t_ˌɪ_t_aɪ_d_z]\
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Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.