CHRONIC ACTINIC DERMATITIS
\kɹˈɒnɪk aktˈɪnɪk dˌɜːmɐtˈa͡ɪtɪs], \kɹˈɒnɪk aktˈɪnɪk dˌɜːmɐtˈaɪtɪs], \k_ɹ_ˈɒ_n_ɪ_k a_k_t_ˈɪ_n_ɪ_k d_ˌɜː_m_ɐ_t_ˈaɪ_t_ɪ_s]\
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Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.